Molecular packing of carbohydrate oligomer encapsulants - a free volume perspective

M. Roussenova, S. Townrow, M. Murith, J. Ubbink, A. Alam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Positron annihilation lifetime spectroscopy (PALS) is used in conjunction with dilatome-try to analyse the effects of water and low molecular weight diluents (maltose and glycerol) on the molecular organisation and density of carbohydrate oligomers commonly used in the pharmaceutical and food industries for the formulation of encapsulation matrices. In the glassy state, both maltose and glycerol act as packing enhancers, causing a non-linear decrease in the average molecular hole size of the carbohydrate matrices. Water exists in a highly non-ideal state in these systems and it alters the molecular organisation of the matrices in a complex manner, whereby it can act either as an anti-plasticiser or a plasticiser, depending on the level of hydration.

Original languageEnglish (US)
Title of host publicationPositron and Positronium Chemistry X
PublisherTrans Tech Publications Ltd
Pages96-99
Number of pages4
ISBN (Print)9783037855188
DOIs
StatePublished - 2013
Externally publishedYes
Event10th International Workshop on Positron and Positronium Chemistry, PPC-10 - Smolenice Castle, Slovakia
Duration: Sep 5 2011Sep 9 2011

Publication series

NameMaterials Science Forum
Volume733
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Conference

Conference10th International Workshop on Positron and Positronium Chemistry, PPC-10
CountrySlovakia
CitySmolenice Castle
Period9/5/119/9/11

Keywords

  • Anti-plasticisation
  • Molecular packing
  • Plasticisation
  • Positron annihilation

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