Molecular MUX-based physical unclonable functions

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


Physical unclonable functions (PUFs) are small circuits that are widely used as hardware security primitives for authentication. These circuits can generate unique signatures because of the inherent randomness in manufacturing and process variations. This paper introduces molecular PUFs based on multiplexer (MUX) PUFs using dual-rail representation. It may be noted that molecular PUFs have not been presented before. Each molecular multiplexer is synthesized using 16 molecular reactions. The intrinsic variations of the rate constants of the molecular reactions are assumed to provide inherent randomness necessary for uniqueness of PUFs. Based on Gaussian distribution of the rate constants of the reactions, this paper simulates intra-chip and inter-chip variations of linear molecular MUX PUFs containing 8, 16, 32 and 64 stages. These variations are, respectively, used to compute reliability and uniqueness. It is shown that, for the rate constants used in this paper, although 8-state molecular MUX PUFs are not useful as PUFs, PUFs containing 16 or higher stages are useful as molecular PUFs. Like electronic PUFs, increasing the number of stages increases uniqueness and reliability of the PUFs.

Original languageEnglish (US)
Title of host publicationProceedings - 2020 IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2020
PublisherIEEE Computer Society
Number of pages6
ISBN (Electronic)9781728157757
StatePublished - Jul 2020
Event19th IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2020 - Limassol, Cyprus
Duration: Jul 6 2020Jul 8 2020

Publication series

NameProceedings of IEEE Computer Society Annual Symposium on VLSI, ISVLSI
ISSN (Print)2159-3469
ISSN (Electronic)2159-3477


Conference19th IEEE Computer Society Annual Symposium on VLSI, ISVLSI 2020

Bibliographical note

Publisher Copyright:
© 2020 IEEE.


  • Molecular MUX PUF
  • Molecular PUF
  • Molecular multiplexers
  • Physical unclonable function (PUF)
  • biomolecular security


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