Molecular mechanisms underlying functional T-cell unresponsiveness

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117 Scopus citations


Evidence from tissue culture experiments and in vivo studies indicates that certain forms of antigen presentatio render T cells unresponsive to subsequent antigenic stimulation. Great progress has been made recently in understanding the induction, maintenance, and in vivo relevance of this unresponsive state, called clonal energy.

Original languageEnglish (US)
Pages (from-to)375-381
Number of pages7
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - 1995


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