Molecular mechanisms of opiate tolerance and dependence in a clonal cell line

A. K. Louie, P. Y. Law, H. H. Loh

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The molecular mechanisms of tolerance and dependence appear to be extremely complex. A unitary mechanism to explain both processes has not been found and some investigations have indicated that separate mechanisms are in fact involved. The neuroblastoma x glioma NG108-15 hybrid cells provide a relatively simple model system with which these complex mechanisms may be elucidated. Only until some understanding is mastered on this single cell level, will more intricate brain systems be comprehensible.

Original languageEnglish (US)
Pages (from-to)117-128
Number of pages12
JournalNIDA Research Monograph Series
VolumeNO. 62
StatePublished - 1985

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