The molecular mechanisms of tolerance and dependence appear to be extremely complex. A unitary mechanism to explain both processes has not been found and some investigations have indicated that separate mechanisms are in fact involved. The neuroblastoma x glioma NG108-15 hybrid cells provide a relatively simple model system with which these complex mechanisms may be elucidated. Only until some understanding is mastered on this single cell level, will more intricate brain systems be comprehensible.
|Original language||English (US)|
|Number of pages||12|
|Journal||NIDA Research Monograph Series|
|State||Published - 1985|