Molecular mechanisms in basement membrane complications of diabetes. Alterations in heparin, laminin, and type IV collagen association

Keyphrases

• Molecular Mechanism 100%
• Diabetes Complications 100%
• Laminin 100%
• Basement Membrane 100%
• Heparin 100%
• Type IV Collagen 100%
• Heparin Binding 41%
• Non-enzymatic Glycation 29%
• High Affinity 11%
• Kd Values 11%
• Low-affinity Binding Sites 11%
• Type 1 Diabetes Mellitus (T1DM) 5%
• Control Condition 5%
• Heparan Sulfate Proteoglycans 5%
• Stoichiometry 5%
• Incubation 5%
• Diabetic Animals 5%
• Dissociation Constant 5%
• Binding Data 5%
• Glycosylation 5%
• Glomerular Basement Membrane 5%
• Binding Properties 5%
• Background Level 5%
• Scatchard Analysis 5%
• Ligand Binding Assay 5%
• Initial Lesions 5%
• Binding Curve 5%
• Non-collagenous Proteins 5%
• Glycosylated Amino Acids 5%
• Heparin Binding Site 5%
• Reduced Type 5%

Neuroscience

• Collagen Type 4 100%
• Basement Membrane 100%
• Heparin 100%
• Laminin 100%
• Glycosylation 35%
• In Vitro 17%
• Binding Site 11%
• Ligand Binding 11%
• Diabetes Mellitus 11%
• Proteoheparan Sulfate 5%
• Amino Acid 5%
• Binding Affinity 5%
• Glomerulus Basement Membrane 5%

Biochemistry, Genetics and Molecular Biology

• Heparin 100%
• Type IV Collagen 100%
• Basement Membrane 100%
• Laminin 100%
• Glycosylation 35%
• Binding Site 11%
• Solution and Solubility 5%
• Amino Acids 5%
• Ligand Binding 5%
• Dissociation Constant 5%
• Binding Affinity 5%
• Glomerulus Basement Membrane 5%
• Stoichiometry 5%
• Proteoglycan 5%
• Scatchard Plot 5%
• Ligand Binding Assay 5%
• Heparan Sulfate 5%