Molecular mechanisms and regulation of opioid receptor signaling

Ping Yee Law, Yung H. Wong, Horace H Loh

Research output: Contribution to journalReview articlepeer-review

517 Scopus citations

Abstract

Cloning of multiple opioid receptors has presented opportunities to investigate the mechanisms of multiple opioid receptor signaling and the regulation of these signals. The subsequent identification of receptor gene structures has also provided opportunities to study the regulation of receptor gene expression and to manipulate the concentration of the gene products in vivo. Thus, in the current review, we examine recent advances in the delineation basis for the multiple opioid receptor signaling, and their regulation at multiple levels. We discuss the use of receptor knockout animals to investigate the function and the pharmacology of these multiple opioid receptors. The reasons and basis for the multiple opioid receptor are addressed.

Original languageEnglish (US)
Pages (from-to)389-430
Number of pages42
JournalAnnual review of pharmacology and toxicology
Volume40
DOIs
StatePublished - 2000

Keywords

  • G proteins
  • Knockout mice
  • Receptor genes
  • Receptor phosphorylation
  • Receptor structure/activity
  • Signal transduction

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