Molecular mechanism of the chemopreventive effect of resveratrol

Zigang Dong

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222 Scopus citations


Chemoprevention is a promising approach to control human cancer. Resveratrol has been shown to have a potent chemopreventive effect in multiple carcinogenesis models. However, the precise mechanism explaining its anti-carcinogenic effect is not clear. This review summarizes recent studies from our laboratory on the mechanisms of resveratrol's effects. In JB6 cells, resveratrol was found to induce apoptosis and inhibit tumor promoter-induced cell transformation. We also found that resveratrol-induced activation of p53 and resveratrol-induced apoptosis occurred through a p53-dependent pathway. The MAP kinases, ERKs, JNKs, or p38 kinases, are involved in resveratrol-induced activation of p53 and apoptosis.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
StatePublished - 2003

Bibliographical note

Funding Information:
This work was supported by The Hormel Foundation and grants funded by American Institute for Cancer Research (99A062) and National Institutes of Health (CA81064).


  • Apoptosis
  • Chemoprevention
  • Resveratrol
  • Signal transduction


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