Molecular genetics of myeloma

Brian Van Ness

doi:10.1007/978-1-4614-3764-2_31

Molecular genetics of myeloma

Brian Van Ness

Genetics, Cell Biology and Development (TMED)

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Multiple myeloma (MM) is a universally fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow [1]. It accounts for 2 % of all cancer deaths and 15 % of all hematologic malignancies, with about 13,000 deaths per year in the USA [2]. In most cases of MM, it is believed to be preceded by a pre-malignant clonal population of plasma cells called monoclonal gammopathy of undetermined significance (MGUS), which is the most common lymphoid tumor in humans [3]. Despite some evidence of familial clustering, the effects of genetic background and environment remain to be clarified. Some early reports of MM risk genes are just emerging.

Original language	English (US)
Title of host publication	Neoplastic Diseases of the Blood
Publisher	Springer New York
Pages	601-613
Number of pages	13
ISBN (Electronic)	9781461437642
ISBN (Print)	1461437636, 9781461437635
DOIs	https://doi.org/10.1007/978-1-4614-3764-2_31
State	Published - Nov 1 2013

Bibliographical note

Publisher Copyright:
© 2013 Springer Science+Business Media New York. All rights reserved.

Keywords

Microarray gene expression
Multiple myeloma
Primary and secondary genetic events
Single-nucleotide polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4614-3764-2_31

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AB - Multiple myeloma (MM) is a universally fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow [1]. It accounts for 2 % of all cancer deaths and 15 % of all hematologic malignancies, with about 13,000 deaths per year in the USA [2]. In most cases of MM, it is believed to be preceded by a pre-malignant clonal population of plasma cells called monoclonal gammopathy of undetermined significance (MGUS), which is the most common lymphoid tumor in humans [3]. Despite some evidence of familial clustering, the effects of genetic background and environment remain to be clarified. Some early reports of MM risk genes are just emerging.

KW - Microarray gene expression

KW - Multiple myeloma

KW - Primary and secondary genetic events

KW - Single-nucleotide polymorphism

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EP - 613

BT - Neoplastic Diseases of the Blood

PB - Springer New York

ER -

Molecular genetics of myeloma

Abstract

Bibliographical note

Keywords

UN SDGs

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