Molecular genetics of myeloma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multiple myeloma (MM) is a universally fatal disease characterized by the accumulation of malignant plasma cells in the bone marrow [1]. It accounts for 2 % of all cancer deaths and 15 % of all hematologic malignancies, with about 13,000 deaths per year in the USA [2]. In most cases of MM, it is believed to be preceded by a pre-malignant clonal population of plasma cells called monoclonal gammopathy of undetermined significance (MGUS), which is the most common lymphoid tumor in humans [3]. Despite some evidence of familial clustering, the effects of genetic background and environment remain to be clarified. Some early reports of MM risk genes are just emerging.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Pages601-613
Number of pages13
ISBN (Electronic)9781461437642
ISBN (Print)1461437636, 9781461437635
DOIs
StatePublished - Nov 1 2013

Keywords

  • Microarray gene expression
  • Multiple myeloma
  • Primary and secondary genetic events
  • Single-nucleotide polymorphism

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