Molecular epidemiology of PRRSV: A phylogenetic perspective

Mang Shi, Tommy Tsan Yuk Lam, Chung Chau Hon, Raymond Kin Hei Hui, Kay S. Faaberg, Trevor Wennblom, Michael P. Murtaugh, Tomasz Stadejek, Frederick Chi Ching Leung

Research output: Contribution to journalReview articlepeer-review

184 Scopus citations

Abstract

Since its first discovery two decades ago, porcine reproductive and respiratory syndrome virus (PRRSV) has been the subject of intensive research due to its huge impact on the worldwide swine industry. Thanks to the phylogenetic analyses, much has been learned concerning the genetic diversity and evolution history of the virus. In this review, we focused on the evolutionary and epidemiological aspects of PRRSV from a phylogenetic perspective. We first described the diversity and transmission dynamics of Type 1 and 2 PRRSV, respectively. Then, we focused on the more ancient evolutionary history of PRRSV: the time of onset of all existing PRRSV and an origin hypothesis were discussed. Finally, we summarized the results from previous recombination studies to assess the potential impact of recombination on the virus epidemiology.

Original languageEnglish (US)
Pages (from-to)7-17
Number of pages11
JournalVirus research
Volume154
Issue number1-2
DOIs
StatePublished - Dec 2010

Keywords

  • Evolution
  • Molecular epidemiology
  • Phylogenetic analyses
  • Porcine reproductive and respiratory syndrome virus

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