Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci

Daniel J. Diekema, Janet I. Andrews, Holly Huynh, Paul R. Rhomberg, Stella R. Doktor, Jill Beyer, Virginia D. Shortridge, Robert K. Flamm, Ronald N. Jones, Michael A. Pfaller

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS.

Original languageEnglish (US)
Pages (from-to)2659-2661
Number of pages3
JournalJournal of clinical microbiology
Volume41
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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