Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes

Keyphrases

• Metabolism 100%
• Human Liver Microsomes 100%
• Molecular Docking 100%
• Enzyme Kinetic Study 100%
• Cytochrome P450 2D6 (CYP2D6) 100%
• Probe Substrate 100%
• Dihydrotanshinone I 100%
• Danshen 71%
• IC50 57%
• Quinidine 57%
• CYP2D6 Activity 57%
• Tanshinone I 57%
• Tanshinone IIA 42%
• Ethanolic Extract 28%
• Dextromethorphan 28%
• Commercially Available 14%
• Water-soluble 14%
• Concentration-dependent 14%
• Amino Acid Residues 14%
• Catalytic Site 14%
• Substrate Binding 14%
• Binding Energy 14%
• Liver Microsomes 14%
• π Interactions 14%
• Active Components 14%
• Water Extract 14%
• Molecular Docking Studies 14%
• Dextrorphan 14%
• O-demethylation 14%
• Salvianolic Acid B 14%
• Cryptotanshinone 14%
• Danshensu 14%
• Active Cavity 14%
• CYP2D6 Inhibitor 14%
• Crytotanshinone 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Enzyme Kinetics 100%
• CYP2D6 100%
• Salvia Miltiorrhiza 55%
• Tanshinone I 44%
• IC50 44%
• Quinidine 44%
• Dextromethorphan 22%
• Tanshinone IIA 22%
• Amino Acid 11%
• Dextrorphan 11%
• Salvianolic Acid B 11%
• Tanshinone 11%
• Cryptotanshinone 11%
• 3 (3,4 Dihydroxyphenyl)lactic Acid 11%
• Cytochrome P450 2D6 Inhibitor 11%