Molecular determinants of pichinde virus infection of guinea pigs - A small animal model system for arenaviral hemorrhagic fevers

Yuying Liang, Shuiyun Lan, Hinh Ly

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Arenaviruses are enveloped single-strand RNA viruses that mostly have natural hosts in rodents. Upon infection of humans, several arenaviruses can cause severe hemorrhagic fever diseases, including Lassa fever that is endemic in West Africa. The virulence mechanism of these deadly arenaviruses can be studied in a safe and economical small animal model - guinea pigs infected by a nonpathogenic arenavirus Pichinde virus (PICV), a virulent strain of which can cause similar disease syndromes in guinea pigs as arenaviral hemorrhagic fevers in humans. We have recently developed molecular clones for both the virulent and avirulent strains of PICV. Using the available reverse genetics tools, we are characterizing the molecular determinants of virulent arenavirus infections in vivo.

Original languageEnglish (US)
Pages (from-to)E65-E74
JournalAnnals of the New York Academy of Sciences
Volume1171
Issue numberSUPPL. 1
DOIs
StatePublished - Sep 2009

Keywords

  • Lassa fever
  • Pichinde virus
  • animal model
  • arenavirus
  • guinea pig
  • reverse genetics system
  • viral hemorrhagic fever
  • virulence factors

Fingerprint Dive into the research topics of 'Molecular determinants of pichinde virus infection of guinea pigs - A small animal model system for arenaviral hemorrhagic fevers'. Together they form a unique fingerprint.

Cite this