Molecular biology of the normal and failing heart

Research output: Chapter in Book/Report/Conference proceedingChapter


Identification of the deoxyribonucleic acid (DNA) double-helix structure by Watson and Crick in 1953 is one of the most significant scientific discoveries (Watson et al., Nature, 171(4356):737-8, 1953). This landmark revelation ushered in the molecular millennium and was critical in establishing the field of molecular medicine. Through significant advances in technology and research in molecular cardiovascular sciences, the molecular and genetic causes of cardiovascular diseases have begun to be established. Further mechanistic insight into cardiovascular disorders has deciphered genetic causes of disease states, established molecular mechanisms for pathophysiological findings, and has resulted in the generation of new therapies to treat these diseases and arrest disease progression. This chapter provides an overview of the current understanding of molecular biology and its impact on cardiovascular medicine.

Original languageEnglish (US)
Title of host publicationCongestive Heart Failure and Cardiac Transplantation
Subtitle of host publicationClinical, Pathology, Imaging and Molecular Profiles
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9783319445779
ISBN (Print)9783319445755
StatePublished - Jun 1 2017


  • Epigenetics
  • Fetal gene program
  • Human genome sequencing
  • MicroRNA
  • Molecular biology and cardiovascular disease
  • Molecular pathways
  • Reverse remodeling of heart failure


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