Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activation

Matthew F. Mescher, Pujya Agarwal, Kerry A. Casey, Christopher D. Hammerbeck, Zhengguo Xiao, Julie M. Curtsinger

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

CD8 T cells specific for self-antigens are present in the peripheral lymphoid system and can contribute to autoimmunity or transplant rejection. Whether recognition of Ag leads to full activation, or to induction of tolerance, depends upon availability of cytokine at critical stages of the response. Signals provided by IL-12 and/or IFN-α/β are required for activation of naïve CD8 T cells, and IL-2 is needed to sustain and further expand the effector cells if Ag persists. These critical signaling requirements provide new insights into the factors that regulate the CD8 T cell contributions to development of autoimmunity or rejection of transplants.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalSeminars in Immunology
Volume19
Issue number3
DOIs
StatePublished - Jun 1 2007

Keywords

  • Activation
  • Anergy
  • CD8 T lymphocyte
  • Differentiation
  • Peripheral tolerance

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    Mescher, M. F., Agarwal, P., Casey, K. A., Hammerbeck, C. D., Xiao, Z., & Curtsinger, J. M. (2007). Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activation. Seminars in Immunology, 19(3), 153-161. https://doi.org/10.1016/j.smim.2007.02.007