Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activation

Matthew F. Mescher; Pujya Agarwal; Kerry A. Casey; Christopher D. Hammerbeck; Zhengguo Xiao; Julie M. Curtsinger

doi:10.1016/j.smim.2007.02.007

Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activation

Matthew F. Mescher, Pujya Agarwal, Kerry A. Casey, Christopher D. Hammerbeck, Zhengguo Xiao, Julie M. Curtsinger

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

CD8 T cells specific for self-antigens are present in the peripheral lymphoid system and can contribute to autoimmunity or transplant rejection. Whether recognition of Ag leads to full activation, or to induction of tolerance, depends upon availability of cytokine at critical stages of the response. Signals provided by IL-12 and/or IFN-α/β are required for activation of naïve CD8 T cells, and IL-2 is needed to sustain and further expand the effector cells if Ag persists. These critical signaling requirements provide new insights into the factors that regulate the CD8 T cell contributions to development of autoimmunity or rejection of transplants.

Original language	English (US)
Pages (from-to)	153-161
Number of pages	9
Journal	Seminars in Immunology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2007.02.007
State	Published - Jun 2007

Bibliographical note

Funding Information:
This work was supported by NIH grants RO1 AI34824 and PO1 AI35296.

Keywords

Activation
Anergy
CD8 T lymphocyte
Differentiation
Peripheral tolerance

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10.1016/j.smim.2007.02.007

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title = "Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activation",

abstract = "CD8 T cells specific for self-antigens are present in the peripheral lymphoid system and can contribute to autoimmunity or transplant rejection. Whether recognition of Ag leads to full activation, or to induction of tolerance, depends upon availability of cytokine at critical stages of the response. Signals provided by IL-12 and/or IFN-α/β are required for activation of na{\"i}ve CD8 T cells, and IL-2 is needed to sustain and further expand the effector cells if Ag persists. These critical signaling requirements provide new insights into the factors that regulate the CD8 T cell contributions to development of autoimmunity or rejection of transplants.",

keywords = "Activation, Anergy, CD8 T lymphocyte, Differentiation, Peripheral tolerance",

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AU - Mescher, Matthew F.

AU - Agarwal, Pujya

AU - Casey, Kerry A.

AU - Hammerbeck, Christopher D.

AU - Xiao, Zhengguo

AU - Curtsinger, Julie M.

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AB - CD8 T cells specific for self-antigens are present in the peripheral lymphoid system and can contribute to autoimmunity or transplant rejection. Whether recognition of Ag leads to full activation, or to induction of tolerance, depends upon availability of cytokine at critical stages of the response. Signals provided by IL-12 and/or IFN-α/β are required for activation of naïve CD8 T cells, and IL-2 is needed to sustain and further expand the effector cells if Ag persists. These critical signaling requirements provide new insights into the factors that regulate the CD8 T cell contributions to development of autoimmunity or rejection of transplants.

KW - Activation

KW - Anergy

KW - CD8 T lymphocyte

KW - Differentiation

KW - Peripheral tolerance

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Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activation

Abstract

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Keywords

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