Molecular architecture of the "stressosome," a signal integration and transduction hub

Jon Marles-Wright, Tim Grant, Olivier Delumeau, Gijs Van Duinen, Susan J. Firbank, Peter J. Lewis, James W. Murray, Joseph A. Newman, Maureen B. Quin, Paul R. Race, Alexis Rohou, Willem Tichelaar, Marin Van Heel, Richard J. Lewis

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress-responsive genes. Stress signals can be integrated by a multiprotein signaling hub that responds to various signals to effect a single outcome. We obtained a medium-resolution cryo-electron microscopy reconstruction of the 1.8-megadalton "stressosome" from Bacillus subtilis. Fitting known crystal structures of components into this reconstruction gave a pseudoatomic structure, which had a virus capsid-like core with sensory extensions. We suggest that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals. The architecture of the stressosome provides the potential for cooperativity, suggesting that the response could be tuned dependent on the magnitude of chemophysical insult.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
Issue number5898
StatePublished - Oct 3 2008


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