Molecular and cellular basis of regeneration and tissue repair: The Xenopus tadpole: A new model for regeneration research

J. M.W. Slack, G. Lin, Y. Chen

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations

Abstract

The Xenopus tadpole is a favourable organism for regeneration research because it is suitable for a wide range of micromanipulative procedures and for a wide range of transgenic methods. Combination of these techniques enables genes to be activated or inhibited at specific times and in specific tissue types to a much higher degree than in any other organism capable of regeneration. Regenerating systems include the tail, the limb buds and the lens. The study of tail regeneration has shown that each tissue type supplies the cells for its own replacement: there is no detectable de-differentiation or metaplasia. Signalling systems needed for regeneration include the BMP and Notch signalling pathways, and perhaps also the Wnt and FGF pathways. The limb buds will regenerate completely at early stages, but not once they are fully differentiated. This provides a good opportunity to study the loss of regenerative ability using transgenic methods. (Part of a Multi-author Review)

Original languageEnglish (US)
Pages (from-to)54-63
Number of pages10
JournalCellular and Molecular Life Sciences
Volume65
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Lens
  • Limb
  • Muscle
  • Notochord
  • Regeneration
  • Satellite cells
  • Spinal cord
  • Xenopus

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