Abstract
Research at the interface of synthetic materials, biochemistry, and analytical techniques has enabled sensing platforms for applications across many research communities. Herein we review the materials used as affinity agents to create surface-enhanced Raman spectroscopy (SERS) sensors. Our scope includes those affinity agents (antibody, aptamer, small molecule, and polymer) that facilitate the intrinsic detection of targets relevant to biology, medicine, national security, environmental protection, and food safety. We begin with an overview of the analytical technique (SERS) and considerations for its application as a sensor. We subsequently describe four classes of affinity agents, giving a brief overview on affinity, production, attachment chemistry, and first uses with SERS. Additionally, we review the SERS features of the affinity agents, and the analytes detected by intrinsic SERS with that affinity agent class. We conclude with remarks on affinity agent selection for intrinsic SERS sensing platforms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31825-31844 |
| Number of pages | 20 |
| Journal | ACS Applied Materials and Interfaces |
| Volume | 10 |
| Issue number | 38 |
| DOIs | |
| State | Published - Sep 26 2018 |
Bibliographical note
Funding Information:This work was supported primarily by the University of Minnesota Industrial Partnership for Interfacial & Materials Engineering. N.V.H.S. acknowledges support through the National Science Foundation Graduate Research Fellowship Program (00039202). We also thank Dr. Renee Frontiera for helpful discussion in this review.
Publisher Copyright:
© 2018 American Chemical Society.
Keywords
- affinity agent
- antibody
- aptamer
- intrinsic SERS
- polymer
- small molecule
- surface-enhanced Raman spectroscopy