Modulatory Role of Serotonin in Neural Information Processing: Implications for Human Psychopathology

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307 Scopus citations

Abstract

Investigation of the role of 5-hydroxytryptophan (5-HT), which functions as a modulator in the central nervous system, across behavioral contexts suggests that a general principle of transmitter function may be derived that is independent of specific behaviors and specific neural loci. A functional principle of 5-HT action in neural information processing in the central nervous system is proposed. Extremes deviations in 5-HT activity result in biases in information processing that may have direct effects on behavior. Such biases may predispose to pathological conditions such as violent suicide and aggression.

Original languageEnglish (US)
Pages (from-to)330-350
Number of pages21
JournalPsychological Bulletin
Volume112
Issue number2
DOIs
StatePublished - Sep 1992

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