Modulation of death receptor-mediated apoptosis by CK2

Guixia Wang, Kashif A. Ahmad, Khalil Ahmed

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Protein kinase CK2 has long been known to be involved in cell growth and proliferation. Recent work has also implicated its role in the suppression of apoptosis. We originally documented that removal of survival or growth stimuli resulted in rapid loss of CK2 from the nuclear matrix and chromatin which preceded induction of apoptosis. Further, we demonstrated that overexpression of CK2 in cells promotes suppression of drug-mediated apoptosis. In the present work, we have extended these observations to demonstrate that CK2 can influence apoptosis mediated via the death receptors. Overexpression of CK2 resulted in suppression of apoptosis mediated by TNF-α, TRAIL, and Fas-L in cells responsive to these ligands, whereas downregulation of CK2 resulted in augmentation of apoptosis mediated by these ligands. To our knowledge, this is the first report to show that receptor-mediated apoptosis can be modulated by changes in CK2 in prostate cancer cells. Based on our previous observations together with the evidence presented here, we propose that CK2 has an impact on the process of apoptosis mediated by diverse type of mechanisms thus playing a global role in regulation of apoptotic activity in cells.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalMolecular and cellular biochemistry
Volume274
Issue number1-2
DOIs
StatePublished - Jun 2005

Bibliographical note

Funding Information:
The work was supported in part by the United States Public Health Service Research Grant UA-15062 awarded by the National Cancer Institute, Department of Health and Human Services, and in part by the Medical Research Fund of the United States Department of Veterans Affairs. We express our deep appreciation for the help provided by Alan T. Davis during the course of these experiments.

Keywords

  • Apoptosis
  • Cancer
  • Down regulation of CK2
  • Inhibition of CK2
  • Over expression of CK2
  • Prostate
  • Protein kinase CK2
  • Receptor-mediated apoptosis
  • Suppression of apoptosis

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