Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes

Frank J. Symons; Chantel C. Burkitt; George Wilcox; Brian McAdams; Gwen Wendelschafer-Crabb; William R. Kennedy

doi:10.1002/dev.22329

Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes

Frank J. Symons, Chantel C. Burkitt, George Wilcox, Brian McAdams, Gwen Wendelschafer-Crabb, William R. Kennedy

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Early tactile and nociceptive (pain) mechanisms in children with global developmental delay at risk for intellectual and developmental disability are not well understood. Sixteen children with global developmental delay (mean age = 5.1 years, SD = 1.4; 50% male) completed a modified quantitative sensory testing (mQST) protocol, an epidermal (skin) punch biopsy procedure, and parent-endorsed measures of pain. Children with reported chronic pain had significantly greater epidermal nerve fiber density (ENFd) compared to children without chronic pain. Based on the mQST trials, ENFd values were associated with increased vocal reactivity overall and specifically during the light touch and cool thermal stimulus trials. The findings support the feasibility of an integrative biobehavioral approach to test nociceptive and tactile peripheral innervation and behavioral reactivity during a standardized sensory test in a high-risk sample for which there is often sensory dysfunction and adaptive behavior impairments.

Original language	English (US)
Article number	e22329
Journal	Developmental psychobiology
Volume	64
Issue number	8
DOIs	https://doi.org/10.1002/dev.22329
State	Published - Dec 2022

Bibliographical note

Funding Information:
This research was supported, in part, by NIH Grants HD44763 and HD73126. In addition, BM received partial support from the RW Goltz Professorship in Dermatology. The authors would like to recognize Breanne Byiers, Adele Dimian, Alyssa Merbler, Kelsey Quest, Lisa Spofford, Elizabeth Steuber, and Cole Hagen for their contribution to this work. The authors express their sincere appreciation to the participating children and their parents who made this study possible.

Funding Information:
This research was supported, in part, by NIH Grants HD44763 and HD73126. In addition, BM received partial support from the RW Goltz Professorship in Dermatology. The authors would like to recognize Breanne Byiers, Adele Dimian, Alyssa Merbler, Kelsey Quest, Lisa Spofford, Elizabeth Steuber, and Cole Hagen for their contribution to this work. The authors express their sincere appreciation to the participating children and their parents who made this study possible.

Publisher Copyright:
© 2022 The Authors. Developmental Psychobiology published by Wiley Periodicals LLC.

Keywords

developmental delay
pain
peripheral innervation
sensory

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10.1002/dev.22329

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Symons, F. J., Burkitt, C. C., Wilcox, G., McAdams, B., Wendelschafer-Crabb, G., & Kennedy, W. R. (2022). Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes. Developmental psychobiology, 64(8), Article e22329. https://doi.org/10.1002/dev.22329

Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes. / Symons, Frank J.; Burkitt, Chantel C.; Wilcox, George et al.
In: Developmental psychobiology, Vol. 64, No. 8, e22329, 12.2022.

Research output: Contribution to journal › Article › peer-review

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abstract = "Early tactile and nociceptive (pain) mechanisms in children with global developmental delay at risk for intellectual and developmental disability are not well understood. Sixteen children with global developmental delay (mean age = 5.1 years, SD = 1.4; 50% male) completed a modified quantitative sensory testing (mQST) protocol, an epidermal (skin) punch biopsy procedure, and parent-endorsed measures of pain. Children with reported chronic pain had significantly greater epidermal nerve fiber density (ENFd) compared to children without chronic pain. Based on the mQST trials, ENFd values were associated with increased vocal reactivity overall and specifically during the light touch and cool thermal stimulus trials. The findings support the feasibility of an integrative biobehavioral approach to test nociceptive and tactile peripheral innervation and behavioral reactivity during a standardized sensory test in a high-risk sample for which there is often sensory dysfunction and adaptive behavior impairments.",

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Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes

Abstract

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