Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders

Arpad Z. Barabas, Chad D. Cole, Arpad D. Barabas, Richard M Graeff, Rene Lafreniere, Donald M. Weir

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Public health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were causing morphological and functional changes of the kidney. The MVT promises, with appropriate case-specific modifications, both preventative and curative applications for ailments, such as endogenous ag initiated mishaps (i.e. autoimmune diseases and cancer) and diseases caused by chronic infection, that are presently only treatable with drugs. To achieve specific immune responses, purified components of the vaccine (ag and antibodies) must be produced and assembled into immune complexes having the potential of inducing predetermined corrective immune response outcomes.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalScandinavian Journal of Immunology
Volume71
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Vaccination
Antigens
Autoimmune Diseases
Therapeutics
Kidney Diseases
Antigen-Antibody Complex
Chronic Disease
Down-Regulation
Vaccines
Public Health
Viruses
Bacteria
Kidney
Antibodies
Infection
Pharmaceutical Preparations
Neoplasms

Cite this

Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders. / Barabas, Arpad Z.; Cole, Chad D.; Barabas, Arpad D.; Graeff, Richard M; Lafreniere, Rene; Weir, Donald M.

In: Scandinavian Journal of Immunology, Vol. 71, No. 3, 01.03.2010, p. 125-133.

Research output: Contribution to journalReview article

Barabas, Arpad Z. ; Cole, Chad D. ; Barabas, Arpad D. ; Graeff, Richard M ; Lafreniere, Rene ; Weir, Donald M. / Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders. In: Scandinavian Journal of Immunology. 2010 ; Vol. 71, No. 3. pp. 125-133.
@article{c585f9822ef24903a50a36da5ef84c26,
title = "Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders",
abstract = "Public health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were causing morphological and functional changes of the kidney. The MVT promises, with appropriate case-specific modifications, both preventative and curative applications for ailments, such as endogenous ag initiated mishaps (i.e. autoimmune diseases and cancer) and diseases caused by chronic infection, that are presently only treatable with drugs. To achieve specific immune responses, purified components of the vaccine (ag and antibodies) must be produced and assembled into immune complexes having the potential of inducing predetermined corrective immune response outcomes.",
author = "Barabas, {Arpad Z.} and Cole, {Chad D.} and Barabas, {Arpad D.} and Graeff, {Richard M} and Rene Lafreniere and Weir, {Donald M.}",
year = "2010",
month = "3",
day = "1",
doi = "10.1111/j.1365-3083.2009.02360.x",
language = "English (US)",
volume = "71",
pages = "125--133",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Modified vaccination technique for prophylactic and therapeutic applications to combat endogenous antigen-induced disorders

AU - Barabas, Arpad Z.

AU - Cole, Chad D.

AU - Barabas, Arpad D.

AU - Graeff, Richard M

AU - Lafreniere, Rene

AU - Weir, Donald M.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Public health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were causing morphological and functional changes of the kidney. The MVT promises, with appropriate case-specific modifications, both preventative and curative applications for ailments, such as endogenous ag initiated mishaps (i.e. autoimmune diseases and cancer) and diseases caused by chronic infection, that are presently only treatable with drugs. To achieve specific immune responses, purified components of the vaccine (ag and antibodies) must be produced and assembled into immune complexes having the potential of inducing predetermined corrective immune response outcomes.

AB - Public health can be protected most effectively through vaccination programmes. However, while presently available vaccination techniques protects the individual by provoking immune responses against exogenous antigens (ags), such as those associated with certain bacteria and viruses, they cannot protect against or treat mishaps caused by endogenous ag. Recently, Barabas and colleagues have developed a new vaccination method, called modified vaccination technique (MVT), which allows the presentation of disease causing agents in such a way as to initiate and maintain desired immune response outcomes even in the context of mishaps associated with endogenous ag. For example, in an experimental autoimmune kidney disease, the MVT downregulated/terminated pathogenic immune responses that were causing morphological and functional changes of the kidney. The MVT promises, with appropriate case-specific modifications, both preventative and curative applications for ailments, such as endogenous ag initiated mishaps (i.e. autoimmune diseases and cancer) and diseases caused by chronic infection, that are presently only treatable with drugs. To achieve specific immune responses, purified components of the vaccine (ag and antibodies) must be produced and assembled into immune complexes having the potential of inducing predetermined corrective immune response outcomes.

UR - http://www.scopus.com/inward/record.url?scp=77449128483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77449128483&partnerID=8YFLogxK

U2 - 10.1111/j.1365-3083.2009.02360.x

DO - 10.1111/j.1365-3083.2009.02360.x

M3 - Review article

C2 - 20415778

AN - SCOPUS:77449128483

VL - 71

SP - 125

EP - 133

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 3

ER -