Modern resuscitation of hemorrhagic shock: what is on the horizon?

D. T. Martin, M. A. Schreiber

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Purpose: Mortality rates among the severely injured remain high. The successful treatment of hemorrhagic shock relies on expeditious control of bleeding through surgical ligation, packing, or endovascular techniques. An important secondary concern in hemorrhaging patients is how to respond to the lost blood volume. A single method that is able to adequately address all needs of the exsanguinating patient has not yet been agreed upon, despite a large growth of knowledge regarding the causative factors of traumatic shock.

Methods: A review of relevent literature was performed.

Conclusions: Many different trials are currently underway to discriminate ways to improve outcomes in the severely injured and bleeding patient.  This paper will review: (1) recent advances in our understanding of the effects hemorrhagic shock has on the coagulation cascade and vascular endothelium, (2) recent research findings that have changed resuscitation, and (3) resuscitation strategies that are not widely used but under active investigation.

Original languageEnglish (US)
Pages (from-to)641-656
Number of pages16
JournalEuropean Journal of Trauma and Emergency Surgery
Issue number6
StatePublished - Nov 29 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.


  • FFP
  • Glycocalyx
  • Hemorrhagic shock
  • Resuscitation
  • Trauma
  • Trauma-induced coagulopathy


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