Models of acute myeloid leukemia: Prospects for drug development and testing

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Abstract

Acute myeloid leukemia (AML) is a common and deadly form of leukemia. New therapies are desperately needed. The availability of appropriate disease model systems is crucial to development of effective treatment. A significant progress in generating and characterizing such model systems has been made in the past decade. Here, the relative benefits of cell lines, transgenic mice and xenografted primary AML model will be compared, along with speculation on new models suitable for AML drug discovery.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalDrug Discovery Today: Disease Models
Volume3
Issue number2
DOIs
StatePublished - Aug 24 2006

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