Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis

Danielle A. Schlosser, Timothy R. Campellone, Bruno Biagianti, Kevin L. Delucchi, David E. Gard, Daniel Fulford, Barbara K. Stuart, Melissa Fisher, Rachel L. Loewy, Sophia Vinogradov

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


A priority for improving outcome in individuals at clinical high risk (CHR) is enhancing our understanding of predictors of psychosis as well as psychosocial functioning. Social functioning, in particular, is a unique indicator of risk as well as an important outcome in itself. Negative symptoms are a significant determinant of social functioning in CHR individuals; yet, it is unclear which specific negative symptoms drive functional outcome and how these symptoms function relative to other predictors, such as neurocognition and mood/anxiety symptoms. In a sample of 85 CHR individuals, we examined whether a two-factor negative symptom structure that is found in schizophrenia (experiential vs expressive symptoms) would be replicated in a CHR sample; and tested the degree to which specific negative symptoms predict social functioning, relative to neurocognition and mood/anxiety symptoms, which are known to predict functioning. The two-factor negative symptom solution was replicated in this CHR sample. Negative symptom severity was found to be uniquely predictive of social functioning, above and beyond depression/anxiety and neurocognition. Experiential symptoms were more strongly associated with social functioning, relative to expression symptoms. In addition, experiential symptoms mediated the relationship between expressive negative symptoms and social functioning. These results suggest that experiences of motivational impairment are more important in determining social functioning, relative to affective flattening and alogia, in CHR individuals, thereby informing the development of more precise therapeutic targets. Developing novel interventions that stimulate goal-directed behavior and reinforce rewarding experiences in social contexts are recommended.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalSchizophrenia Research
Issue number1-3
StatePublished - Dec 1 2015

Bibliographical note

Funding Information:
This research was supported by the following funding sources: NIMH K23 MH097795-01 (Schlosser); NIMH R34 MH100399 (Schlosser/Vinogradov); and NIMH R01 01MH081051 (Vinogradov). The funding sources had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Copyright 2017 Elsevier B.V., All rights reserved.


  • Experiential negative symptoms
  • Expressive negative symptoms
  • Motivation
  • Prodromal
  • Psychosis
  • Social functioning


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