Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis

Pei Yao Zhai; Zhi Xian Chen; Ting Jiang; Jian Feng; Bin Zhang; Xiao Zang; Yan Lin Zhao; Gang Qin

doi:10.1016/j.drup.2024.101172

Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis

Pei Yao Zhai, Zhi Xian Chen, Ting Jiang, Jian Feng, Bin Zhang, Xiao Zang, Yan Lin Zhao, Gang Qin

Health Policy and Management

Research output: Contribution to journal › Article › peer-review

Abstract

This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need for second-line treatment, offering a promising approach to mitigate DR-TB burden by 2050.

Original language	English (US)
Article number	101172
Journal	Drug Resistance Updates
Volume	78
DOIs	https://doi.org/10.1016/j.drup.2024.101172
State	Published - Jan 2025

Bibliographical note

Publisher Copyright:
© 2024 The Authors

Keywords

Drug resistance
Mathematical model
Tuberculosis
Vaccine

PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.drup.2024.101172

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title = "Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis",

abstract = "This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need for second-line treatment, offering a promising approach to mitigate DR-TB burden by 2050.",

keywords = "Drug resistance, Mathematical model, Tuberculosis, Vaccine",

author = "Zhai, {Pei Yao} and Chen, {Zhi Xian} and Ting Jiang and Jian Feng and Bin Zhang and Xiao Zang and Zhao, {Yan Lin} and Gang Qin",

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language = "English (US)",

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AU - Zhai, Pei Yao

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AU - Jiang, Ting

AU - Feng, Jian

AU - Zhang, Bin

AU - Zang, Xiao

AU - Zhao, Yan Lin

AU - Qin, Gang

PY - 2025/1

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N2 - This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need for second-line treatment, offering a promising approach to mitigate DR-TB burden by 2050.

AB - This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need for second-line treatment, offering a promising approach to mitigate DR-TB burden by 2050.

KW - Drug resistance

KW - Mathematical model

KW - Tuberculosis

KW - Vaccine

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Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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