Modeling of gene regulatory processes by population-mediated signaling: New applications of population balances

Che Chi Shu, Anushree Chatterjee, Wei Shou Hu, Doraiswami Ramkrishna

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Population balance modeling is considered for cell populations in gene regulatory processes in which one or more intracellular variables undergo stochastic dynamics as determined by Ito stochastic differential equations. This paper addresses formulation and computational issues with sample applications to the spread of drug resistance among bacterial cells. It is shown that predictions from population balances can display qualitative differences from those made with single cell models which are usually encountered in the literature. Such differences are deemed to be important.

Original languageEnglish (US)
Pages (from-to)188-199
Number of pages12
JournalChemical Engineering Science
Volume70
DOIs
StatePublished - Mar 5 2012

Keywords

  • Biological and biomolecular engineering
  • Drug resistance transfer
  • Formulation
  • Gene regulatory processes
  • Mathematical modeling
  • Population balance

Fingerprint Dive into the research topics of 'Modeling of gene regulatory processes by population-mediated signaling: New applications of population balances'. Together they form a unique fingerprint.

Cite this