Model studies of blood-glucose regulation

Eugene Ackerman, Lael C Gatewood, John W. Rosevear, George D. Molnar

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


A simplified, linearized model of the system regulating blood-glucose concentrations is reviewed. This model, which predicts a damped sine wave response to an oral glucose load, lumps the large number of kinetic parameters into a much smaller number which can, at least in part, characterize the human glucose regulatory system. The predictions based on the model are compared with measurements of blood-glucose and blood-insulin concentrations during the oral glucose-tolerance test. Various other conditions are simulated and their implications are discussed in terms of the mathematical model used.

Original languageEnglish (US)
Pages (from-to)21-37
Number of pages17
JournalThe Bulletin of Mathematical Biophysics
Issue number1 Supplement
StatePublished - Jan 1 1965


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