Model of RecA-mediated homologous recognition

Kevin D. Dorfman; Renaud Fulconis; Marie Dutreix; Jean Louis Viovy

doi:10.1103/PhysRevLett.93.268102

Model of RecA-mediated homologous recognition

Kevin D. Dorfman, Renaud Fulconis, Marie Dutreix, Jean Louis Viovy

Chemical Engineering and Materials Science

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The use of a minimal model to examine the homology search between a long double-stranded DNA and a RecA-single stranded DNA nucleofilament was discussed. The model was used to emphasize the polymeric nature of the search and the ability of double stranded DNA to overcome the difference in pitch between itself and the nucleofilament. The analytical first-passage-time analysis predicted new dependencies on the intracellular fluid viscosity and ionic strength. The results show that the initial homologous recognition involved a three base-pair seed.

Original language	English (US)
Article number	268102
Journal	Physical review letters
Volume	93
Issue number	26 I
DOIs	https://doi.org/10.1103/PhysRevLett.93.268102
State	Published - Dec 31 2004

Bibliographical note

Funding Information:
K. D. D. acknowledges financial support from the Human Frontier Science Program and Institut Curie. R. F. acknowledges financial support from DGA-CNRS. This work was supported by CNRS Nano-objects/Nanoscience Programme.

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abstract = "The use of a minimal model to examine the homology search between a long double-stranded DNA and a RecA-single stranded DNA nucleofilament was discussed. The model was used to emphasize the polymeric nature of the search and the ability of double stranded DNA to overcome the difference in pitch between itself and the nucleofilament. The analytical first-passage-time analysis predicted new dependencies on the intracellular fluid viscosity and ionic strength. The results show that the initial homologous recognition involved a three base-pair seed.",

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note = "Funding Information: K. D. D. acknowledges financial support from the Human Frontier Science Program and Institut Curie. R. F. acknowledges financial support from DGA-CNRS. This work was supported by CNRS Nano-objects/Nanoscience Programme.",

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Model of RecA-mediated homologous recognition

Abstract

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