Model of RecA-mediated homologous recognition

Kevin D. Dorfman, Renaud Fulconis, Marie Dutreix, Jean Louis Viovy

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13 Scopus citations

Abstract

The use of a minimal model to examine the homology search between a long double-stranded DNA and a RecA-single stranded DNA nucleofilament was discussed. The model was used to emphasize the polymeric nature of the search and the ability of double stranded DNA to overcome the difference in pitch between itself and the nucleofilament. The analytical first-passage-time analysis predicted new dependencies on the intracellular fluid viscosity and ionic strength. The results show that the initial homologous recognition involved a three base-pair seed.

Original languageEnglish (US)
Article number268102
JournalPhysical review letters
Volume93
Issue number26 I
DOIs
StatePublished - Dec 31 2004

Bibliographical note

Funding Information:
K. D. D. acknowledges financial support from the Human Frontier Science Program and Institut Curie. R. F. acknowledges financial support from DGA-CNRS. This work was supported by CNRS Nano-objects/Nanoscience Programme.

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