Minnesota Multiphasic Personality Inventory (MMPI) profiles completed during unambiguous manic, depressed, and euthymic periods were compared in a sample of 22 bipolar (manic-depressive) patients, 13 females and 9 males, drawn from an outpatient psychiatry clinic; each patient was "multiplex-selected" in that each had a first-degree relative with a severe psychiatric disorder. Both the manic and depressed phase MMPIs revealed significant and prototypical signs of psychopathology corresponding with the clinical picture. In contrast, the mean remission profile was entirely within normal limits. At least in some individuals, bipolar disorder seems to be associated with complete restitution of normality.
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Acknowledgments. Research for and preparation of this article were supported in part by a training grant to the University of Minnesota, MH-10679, and by grants from the National Institute of Mental Health, MH-31302 and MH-29689 to the Departments of Psychiatry, Washington University School of Medicine and St. Paul-Ramsey Medical Center, respectively, along with support from the St. Paul-Ramsey Hospital Medical Education and Research Foundation.
- Bipolar disorder
- Minnesota Multiphasic Personality Inventory
- family history
- multiplex selection