MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study

Thien N. Sam; John H. Kersey; Amy M Linabery; Kimberly J. Johnson; Nyla A. Heerema; Joanne M. Hilden; Stella M. Davies; Gregory H. Reaman; Julie A Ross

doi:10.1002/pbc.23274

MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study

Thien N. Sam, John H. Kersey, Amy M Linabery, Kimberly J. Johnson, Nyla A. Heerema, Joanne M. Hilden, Stella M. Davies, Gregory H. Reaman, Julie A Ross

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Abstract

Background: Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. Procedure: Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. Results: Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases. Conclusion: These patterns may provide important etiological insight into the biology of infant leukemia.

Original language	English (US)
Pages (from-to)	836-839
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	58
Issue number	6
DOIs	https://doi.org/10.1002/pbc.23274
State	Published - Jun 2012

Keywords

Epidemiology
Infants
Leukemia
MLL

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10.1002/pbc.23274

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title = "MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study",

abstract = "Background: Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. Procedure: Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. Results: Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases. Conclusion: These patterns may provide important etiological insight into the biology of infant leukemia.",

keywords = "Epidemiology, Infants, Leukemia, MLL",

author = "Sam, {Thien N.} and Kersey, {John H.} and Linabery, {Amy M} and Johnson, {Kimberly J.} and Heerema, {Nyla A.} and Hilden, {Joanne M.} and Davies, {Stella M.} and Reaman, {Gregory H.} and Ross, {Julie A}",

year = "2012",

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doi = "10.1002/pbc.23274",

language = "English (US)",

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TY - JOUR

T1 - MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors

T2 - A Children's Oncology Group (COG) study

AU - Sam, Thien N.

AU - Kersey, John H.

AU - Linabery, Amy M

AU - Johnson, Kimberly J.

AU - Heerema, Nyla A.

AU - Hilden, Joanne M.

AU - Davies, Stella M.

AU - Reaman, Gregory H.

AU - Ross, Julie A

PY - 2012/6

Y1 - 2012/6

N2 - Background: Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. Procedure: Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. Results: Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases. Conclusion: These patterns may provide important etiological insight into the biology of infant leukemia.

AB - Background: Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. Procedure: Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. Results: Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases. Conclusion: These patterns may provide important etiological insight into the biology of infant leukemia.

KW - Epidemiology

KW - Infants

KW - Leukemia

KW - MLL

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MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children's Oncology Group (COG) study

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