Mixed-drove spatio-temporal co-occurrence patterns (MDCOPs) represent subsets of object-types that are located together in space and time. Discovering MDCOPs is an important problem with many applications such as identifying tactics in battlefields, games, and predator-prey interactions. However, mining MDCOPs is computationally very expensive because the interest measures are computationally complex, datasets are larger due to the archival history, and the set of candidate patterns is exponential in the number of object-types. We propose a monotonie composite interest measure for discovering MDCOPs and a novel MDCOP mining algorithm. Analytical and experimental results show that the proposed algorithm is correct and complete. Results also show the proposed method is computationally more efficient than naïve alternatives.