Mitral Valve Perforation in Libman–Sacks Endocarditis: A Heart-Wrenching Case of Lupus

Elizabeth S. Aby, Zachary Rosol, Mengistu A Simegn

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Libman–Sacks (LS) endocarditis is one of the most common cardiac manifestations of systemic lupus erythematosus. Rarely, however, it can lead to serious complications, including severe valvular regurgitation or superimposed bacterial endocarditis. We describe the initial diagnostic challenges, clinical course, imaging studies and histopathological findings of a patient who presented with life-threatening lupus complicated by hemoptysis and respiratory failure secondary to a rare complication of LS endocarditis, acute mitral valve perforation. We review the current literature on valve perforation in the setting of LS endocarditis. In conclusion, although the disease is often asymptomatic and hemodynamically insignificant, it can result in serious and potentially fatal complications secondary to valve perforation, which may demand emergency surgical management.

Original languageEnglish (US)
Pages (from-to)964-969
Number of pages6
JournalJournal of general internal medicine
Issue number8
StatePublished - Aug 1 2016

Bibliographical note

Funding Information:
There were no funding sources, grants, or other financial support.

Publisher Copyright:
© 2016, Society of General Internal Medicine.


  • Libman–Sacks endocarditis
  • endocarditis
  • lupus carditis
  • valve perforation
  • vegetation


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