Mitotic spindle: Disturbing a subtle balance

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations


Mitotic spindles maintain a roughly constant length in metaphase, so the forces between the spindle poles are balanced. A new study involving screening molecules believed to mediate this force balance has found that spindle length is relatively insensitive to perturbations of molecular motor force-generating activities, but more sensitive to perturbation of microtubule assembly regulators and chromosome cohesion.

Original languageEnglish (US)
Pages (from-to)R956-R959
JournalCurrent Biology
Issue number23
StatePublished - Dec 6 2005


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