Mitochondrial dysfunction modulates nonlinear dynamics in liver cell metabolism

V. Krishnan Ramanujan, Brian A. Herman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Regulatory dynamics of energy metabolism in living cells entails a coordinated response of multiple enzyme networks that operate under non-equilibrium conditions. Here we show that mitochondrial dysfunctions associated with the aging process significantly modify nonlinear dynamical signatures in free radical generation/removal thereby altering energy metabolism in liver cells. Combining high spatial and temporal resolution imaging and bio-energetic measurements, our work provides experimental support to the hypothesis that mitochondria manifest nonlinear dynamical behavior for efficiently regulating energy metabolism in intact cells and any partial or complete reduction in this behavior would contribute to organ dysfunctions including aging process and other disease processes.

Original languageEnglish (US)
Title of host publicationComplex Dynamics and Fluctuations in Biomedical Photonics IV
DOIs
StatePublished - Aug 31 2007
EventComplex Dynamics and Fluctuations in Biomedical Photonics IV - San Jose, CA, United States
Duration: Jan 20 2007Jan 23 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6436
ISSN (Print)1605-7422

Conference

ConferenceComplex Dynamics and Fluctuations in Biomedical Photonics IV
CountryUnited States
CitySan Jose, CA
Period1/20/071/23/07

Keywords

  • Aging
  • Detrended fluctuation analysis
  • Metabolism
  • Mitochondria
  • Nonlinear dynamics

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    Ramanujan, V. K., & Herman, B. A. (2007). Mitochondrial dysfunction modulates nonlinear dynamics in liver cell metabolism. In Complex Dynamics and Fluctuations in Biomedical Photonics IV [64360G] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6436). https://doi.org/10.1117/12.701089