Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca

Translated title of the contribution: Mitochondrial dynamics: A potential new therapeutic target for heart failure

Jovan Kuzmicic, Andrea Del Campo, Camila López-Crisosto, Pablo E. Morales, Christian Pennanen, Roberto Bravo-Sagua, Jonathan Hechenleitner, Ramiro Zepeda, Pablo F. Castro, Hugo E. Verdejo, Valentina Parra, Mario Chiong, Sergio Lavandero

Research output: Contribution to journalShort surveypeer-review

54 Scopus citations

Abstract

Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy. Although the majority of these studies have been confined to noncardiac cells, emerging evidence suggests that changes in mitochondrial morphology could participate in cardiac development, the response to ischemia-reperfusion injury, heart failure, and diabetes mellitus. In this article, we review how the mitochondrial dynamics are altered in different cardiac pathologies, with special emphasis on heart failure, and how this knowledge may provide new therapeutic targets for treating cardiovascular diseases.

Translated title of the contributionMitochondrial dynamics: A potential new therapeutic target for heart failure
Original languageSpanish
Pages (from-to)916-923
Number of pages8
JournalRevista Espanola de Cardiologia
Volume64
Issue number10
DOIs
StatePublished - Oct 2011

Keywords

  • Cardiac metabolism
  • Heart failure
  • Mitochondria
  • Mitochondrial dynamics

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