Mitochondrial DNA variants influence mitochondrial bioenergetics in Drosophila melanogaster

C. C. Correa, W. C. Aw, R. G. Melvin, N. Pichaud, J. W.O. Ballard

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


The influence of mitochondrial DNA (mtDNA) mutations on human disease has been extensively studied, but the impact of mutations within the adaptive range is debated. We studied males from lines of Drosophila melanogaster that have a highly standardized nuclear genome but different mtDNA, at two ages. We measured mitochondrial respiration on permeabilized muscle fibers, hydrogen peroxide production of isolated mitochondria and mtDNA copy number of whole individuals. The results show that a small set of naturally occurring mtDNA mutations can have a significant influence on mitochondrial bioenergetics that may change as the organism ages.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
Issue number4
StatePublished - Jul 2012
Externally publishedYes

Bibliographical note

Funding Information:
The work was supported by University of New South Wales internal grants and ARC grant DP110104542 . Members of the Ballard Lab and an anonymous reviewer provided useful comments on a draft of the manuscript.


  • Mitochondrial bioenergetics
  • MtDNA copy number
  • Reactive oxygen species


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