Mitochondrial DNA alterations and reduced mitochondrial function in aging

Sadie L. Hebert, Ian R. Lanza, K. Sreekumaran Nair

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.

Original languageEnglish (US)
Pages (from-to)451-462
Number of pages12
JournalMechanisms of Ageing and Development
Volume131
Issue number7-8
DOIs
StatePublished - Jul 1 2010

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Mitochondrial DNA
Mitochondrial Proteins
DNA Replication

Keywords

  • Aging
  • Mitochondria
  • Mitochondrial DNA

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Mitochondrial DNA alterations and reduced mitochondrial function in aging. / Hebert, Sadie L.; Lanza, Ian R.; Nair, K. Sreekumaran.

In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 01.07.2010, p. 451-462.

Research output: Contribution to journalArticle

Hebert, Sadie L. ; Lanza, Ian R. ; Nair, K. Sreekumaran. / Mitochondrial DNA alterations and reduced mitochondrial function in aging. In: Mechanisms of Ageing and Development. 2010 ; Vol. 131, No. 7-8. pp. 451-462.
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