Mitochondrial diabetology

Jarmila Kucharská, Anna Gvozdjáková, Ram B. Singh, Viliam Mojto, Germaine G Cornelissen-Guillaume

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Diabetes mellitus (DM) is associated with both impaired insulin release from pancreatic β-cells and with impaired insulin action in insulin-sensitive tissues. Mitochondrial dysfunction plays a role in both processes and in the development of diabetic complications. Impaired mitochondrial bioenergetics and deficiency of coenzyme Q10, an essential part of the respiratory chain, contribute to increased generation of reactive oxygen species. Diabetic brain and heart mitochondrial oxidative phosphorylation and coenzyme Q10 concentrations correlate with each other and are also subject to circadian variations. Changed mitochondrial biological rhythms found in an experimental diabetic model may contribute to a better understanding of the mechanisms of acute myocardial infarction, stroke and sudden death in diabetic patients.

Original languageEnglish (US)
Title of host publicationRecent Advances in Mitochondrial Medicine and Coenzyme Q 10
PublisherNova Science Publishers, Inc.
Pages145-154
Number of pages10
ISBN (Electronic)9781536131505
ISBN (Print)9781536131499
StatePublished - Jan 1 2018

Keywords

  • Circadian rhythms
  • Coenzyme Q
  • Diabetes mellitus
  • Metabolism
  • Mitochondria
  • Oxidative phosphorylation

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  • Cite this

    Kucharská, J., Gvozdjáková, A., Singh, R. B., Mojto, V., & Cornelissen-Guillaume, G. G. (2018). Mitochondrial diabetology. In Recent Advances in Mitochondrial Medicine and Coenzyme Q 10 (pp. 145-154). Nova Science Publishers, Inc..