Abstract
Mitochondrial dysfunction is involved in the pathology of two major blinding retinal diseases, diabetic retinopathy (DR) and age-related macular degeneration (AMD). These diseases accumulate mitochondrial defects in distinct retinal subcellular structures, the vascular/neural network in DR and the retinal pigment epithelium (RPE) in AMD. These mitochondrial defects cause a metabolic crisis that drives disease. With no treatments to stop these diseases, coupled with an increasing population suffering from AMD and DR, there is an urgent need to develop new therapeutics targeting the mitochondria to prevent or reverse disease-specific pathology.
Original language | English (US) |
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Pages (from-to) | 105-118 |
Number of pages | 14 |
Journal | Trends in Molecular Medicine |
Volume | 26 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2020 |
Bibliographical note
Funding Information:We acknowledge the contributions of laboratory associates (past and present) to the work cited in this review, Nikhil S. Sahajpal for his help in preparing the initial draft, Jorge Polanco for help with developing figures, and Parvathy Hariharan for editorial assistance. National Institutes of Health (T32 AG029796), VitroRetinal Surgery Foundation Fellowship to C.R.F.; National Institutes of Health (NEI EY028554 and EY026012), Elaine and Robert Larson Endowed Research Chair, Anonymous Benefactor for Macular Degeneration Research, Lindsay Family Foundation to D.A.F.; National Institutes of Health (EY014370, EY017313, and EY022230) and The Thomas Foundation to R.A.K.; and an unrestricted grant from Research to Prevent Blindness to the WSU’s Ophthalmology Department.
Funding Information:
We acknowledge the contributions of laboratory associates (past and present) to the work cited in this review, Nikhil S. Sahajpal for his help in preparing the initial draft, Jorge Polanco for help with developing figures, and Parvathy Hariharan for editorial assistance. National Institutes of Health (T32 AG029796), VitroRetinal Surgery Foundation Fellowship to C.R.F.; National Institutes of Health (NEI EY028554 and EY026012), Elaine and Robert Larson Endowed Research Chair, Anonymous Benefactor for Macular Degeneration Research, Lindsay Family Foundation to D.A.F.; National Institutes of Health (EY014370, EY017313, and EY022230) and The Thomas Foundation to R.A.K.; and an unrestricted grant from Research to Prevent Blindness to the WSU's Ophthalmology Department. D.A.F. has received past research funds from Stealth BioTherapeutics.
Publisher Copyright:
© 2019 Elsevier Ltd
Keywords
- age-related macular degeneration
- diabetes
- mitochondria
- retinopathy
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Review