Mitochondrial Defects Drive Degenerative Retinal Diseases

Deborah A. Ferrington, Cody R. Fisher, Renu A. Kowluru

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Mitochondrial dysfunction is involved in the pathology of two major blinding retinal diseases, diabetic retinopathy (DR) and age-related macular degeneration (AMD). These diseases accumulate mitochondrial defects in distinct retinal subcellular structures, the vascular/neural network in DR and the retinal pigment epithelium (RPE) in AMD. These mitochondrial defects cause a metabolic crisis that drives disease. With no treatments to stop these diseases, coupled with an increasing population suffering from AMD and DR, there is an urgent need to develop new therapeutics targeting the mitochondria to prevent or reverse disease-specific pathology.

Original languageEnglish (US)
Pages (from-to)105-118
Number of pages14
JournalTrends in Molecular Medicine
Volume26
Issue number1
DOIs
StatePublished - Jan 2020

Bibliographical note

Funding Information:
We acknowledge the contributions of laboratory associates (past and present) to the work cited in this review, Nikhil S. Sahajpal for his help in preparing the initial draft, Jorge Polanco for help with developing figures, and Parvathy Hariharan for editorial assistance. National Institutes of Health (T32 AG029796), VitroRetinal Surgery Foundation Fellowship to C.R.F.; National Institutes of Health (NEI EY028554 and EY026012), Elaine and Robert Larson Endowed Research Chair, Anonymous Benefactor for Macular Degeneration Research, Lindsay Family Foundation to D.A.F.; National Institutes of Health (EY014370, EY017313, and EY022230) and The Thomas Foundation to R.A.K.; and an unrestricted grant from Research to Prevent Blindness to the WSU’s Ophthalmology Department.

Funding Information:
We acknowledge the contributions of laboratory associates (past and present) to the work cited in this review, Nikhil S. Sahajpal for his help in preparing the initial draft, Jorge Polanco for help with developing figures, and Parvathy Hariharan for editorial assistance. National Institutes of Health (T32 AG029796), VitroRetinal Surgery Foundation Fellowship to C.R.F.; National Institutes of Health (NEI EY028554 and EY026012), Elaine and Robert Larson Endowed Research Chair, Anonymous Benefactor for Macular Degeneration Research, Lindsay Family Foundation to D.A.F.; National Institutes of Health (EY014370, EY017313, and EY022230) and The Thomas Foundation to R.A.K.; and an unrestricted grant from Research to Prevent Blindness to the WSU's Ophthalmology Department. D.A.F. has received past research funds from Stealth BioTherapeutics.

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

  • age-related macular degeneration
  • diabetes
  • mitochondria
  • retinopathy

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

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