TY - JOUR
T1 - Mitochondriálna kardiológia
AU - Gvozdjakova, A.
AU - Kucharska, J.
AU - Cornelissen-Guillaume, Germaine G
AU - Singh, R. B.
AU - Simko, F.
N1 - Publisher Copyright:
© 2014 AEPress s.r.o.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Mitochondrial Cardiology is part of Mitochondrial Medicine, which provides a comprehensive view of mitochondrial disease in terms of clinical, metabolic, genetic and pathological information relevant to the diagnosis and treatment of mitochondrial diseases. Mitochondrial cardiology highlights the irreplaceable importance of mitochondria in the heart muscle in terms of generating the required amount of energy in the form of ATP through oxidative phosphorylation and reducing oxidative stress. Mitochondrial respiratory chain complexes – I, III and IV form stable supercomplexes that contribute to the elucidation of the causes of mitochondrial diseases. The dynamics of mitochondria is controlled by processes that regulate mitochondrial dynamics: biogenesis, fission, fusion and mitophagy. In mitochondria, NAD+ – dependent deacylases – sirtuins (SIRT 3, 4 and 5) signalling stress or cell damage are located. Mitochondrial oxidative phosphorylation, and the heart muscle coenzyme Q10 are controlled by circadian and circasemidian rhythms. Supported therapy with coenzyme Q10 in patients with cardiovascular diseases has a significant role in preventing the development of cardiovascular complications, in improving cardiac muscle function in patients waiting for cardiac transplantation. Targeting therapy with coenzyme Q10 is also of potential importance in preventing the onset and development of heart transplant rejection, reducing the cost of hospitalization and treating patients with cardiovascular diseases, and offering prospective cardiologists access to prevention and targeting therapy of heart muscle damaged mitochondrial function. Fig. 8, Ref. 50, Online full text (Free, PDF) www.cardiology.sk
AB - Mitochondrial Cardiology is part of Mitochondrial Medicine, which provides a comprehensive view of mitochondrial disease in terms of clinical, metabolic, genetic and pathological information relevant to the diagnosis and treatment of mitochondrial diseases. Mitochondrial cardiology highlights the irreplaceable importance of mitochondria in the heart muscle in terms of generating the required amount of energy in the form of ATP through oxidative phosphorylation and reducing oxidative stress. Mitochondrial respiratory chain complexes – I, III and IV form stable supercomplexes that contribute to the elucidation of the causes of mitochondrial diseases. The dynamics of mitochondria is controlled by processes that regulate mitochondrial dynamics: biogenesis, fission, fusion and mitophagy. In mitochondria, NAD+ – dependent deacylases – sirtuins (SIRT 3, 4 and 5) signalling stress or cell damage are located. Mitochondrial oxidative phosphorylation, and the heart muscle coenzyme Q10 are controlled by circadian and circasemidian rhythms. Supported therapy with coenzyme Q10 in patients with cardiovascular diseases has a significant role in preventing the development of cardiovascular complications, in improving cardiac muscle function in patients waiting for cardiac transplantation. Targeting therapy with coenzyme Q10 is also of potential importance in preventing the onset and development of heart transplant rejection, reducing the cost of hospitalization and treating patients with cardiovascular diseases, and offering prospective cardiologists access to prevention and targeting therapy of heart muscle damaged mitochondrial function. Fig. 8, Ref. 50, Online full text (Free, PDF) www.cardiology.sk
KW - Chronobiology
KW - Coenzyme Q
KW - Mitochondrial cardiology
KW - Mitochondrial dynamics
KW - Sirtuins
KW - Supercomplexes
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M3 - Article
AN - SCOPUS:85022202787
SN - 1338-3655
VL - 26
SP - 145
EP - 163
JO - Cardiology Letters
JF - Cardiology Letters
IS - 3
ER -