Missed myocardial infarctions in ED patients prospectively categorized as low risk by established risk scores

A. J. Singer, M. P. Than, S. Smith, P. McCullough, T. W. Barrett, R. Birkhahn, M. Reed, H. C. Thode, W. D. Arnold, L. B. Daniels, C. de Filippi, G. Headden, W. F. Peacock

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Study objectives Few studies have prospectively compared multiple cardiac risk prediction scores. We compared the rate of missed acute myocardial infarction (AMI) in chest pain patients prospectively categorized as low risk by unstructured clinical impression, and by HEART, TIMI, GRACE, and EDACS scores, in combination with two negative contemporary cardiac troponins (cTn) available in the U.S. Methods We enrolled 434 patients with chest pain presenting to one of seven emergency departments (ED). Risk scores were prospectively calculated and included the first two cTn. Low risk was defined for each score as HEART ≤ 3, TIMI ≤ 0, GRACE ≤ 50, and EDACS ≤ 15. AMI incidence was calculated for low risk patients and compared across scores using Χ2 tests and C statistics. Results The patients’ median age was 57, 58% were male, 60% white, and 80 (18%) had AMI. The missed AMI rate in low risk patients for each of the scores when combined with 2 cTn were HEART 3.6%, TIMI 0%, GRACE 6.3%, EDACS 0.9%, and unstructured clinical impression 0%. The C-statistic was greatest for the EDACS score, 0.94 (95% CI, 0.92–0.97). Conclusions Using their recommended cutpoints and non high sensitivity cTn, TIMI and unstructured clinical impression were the only scores with no missed cases of AMI. Using lower cutpoints (GRACE ≤ 48, TIMI = 0, EDACS ≤ 11, HEART ≤ 2) missed no case of AMI, but classified less patients as low-risk.

Original languageEnglish (US)
Pages (from-to)704-709
Number of pages6
JournalAmerican Journal of Emergency Medicine
Issue number5
StatePublished - May 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.


Dive into the research topics of 'Missed myocardial infarctions in ED patients prospectively categorized as low risk by established risk scores'. Together they form a unique fingerprint.

Cite this