Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation center

Jeffrey McCullough, David McKenna, Diane Kadidlo, David Maurer, Harriett J. Noreen, Kathy French, Claudio Brunstein, John E. Wagner

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We instituted procedures to check the identity of cord blood unit provided for transplantation by carrying out ABO and human leukocyte antigen (HLA) typing of the thawed units before transplantation. ABO typing is done using standard techniques. Rapid HLAclass I serology is with monoclonal antibody trays (One Lambda Inc) using standard incubations. One mislabeled umbilical cord blood (UCB) unit was detected on the day of intended transplantation by repeat ABO typing of the thawed unit at our transplantation center. Because ABO typing will not detect all labeling errors, the rapid serologic class I HLA typing procedure was done on thawed units just before transplantation for all units without an attached segment. This procedure identified a second mislabeled unit. In a 6-year period, 2 of 871 (0.2%) cord blood units sent to us for transplantation were mislabeled and potentially would have been transplanted incorrectly. This error rate of 1 per 249 (0.4%) patients could have potentially devastating consequences.

Original languageEnglish (US)
Pages (from-to)1684-1688
Number of pages5
JournalBlood
Volume114
Issue number8
DOIs
StatePublished - 2009

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