Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Dawn M. Dudley; Koen K. Van Rompay; Lark L. Coffey; Amir Ardeshir; Rebekah I. Keesler; Eliza Bliss-Moreau; Peta L. Grigsby; Rosemary J. Steinbach; Alec J. Hirsch; Rhonda P. MacAllister; Heidi L. Pecoraro; Lois M. Colgin; Travis Hodge; Daniel N. Streblow; Suzette Tardif; Jean L. Patterson; Manasi Tamhankar; Maxim Seferovic; Kjersti M. Aagaard; Claudia Sánchez San Martín; Charles Y. Chiu; Antonito T. Panganiban; Ronald S. Veazey; Xiaolei Wang; Nicholas J. Maness; Margaret H. Gilbert; Rudolf P. Bohm; Kristina M. Adams Waldorf; Michael Gale; Lakshmi Rajagopal; Charlotte E. Hotchkiss; Emma L. Mohr; Saverio V. Capuano; Heather A. Simmons; Andres Mejia; Thomas C. Friedrich; Thaddeus G. Golos; David H. O’Connor

doi:10.1038/s41591-018-0088-5

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Dawn M. Dudley
, Koen K. Van Rompay
, Lark L. Coffey
, Amir Ardeshir
, Rebekah I. Keesler
, Eliza Bliss-Moreau
, Peta L. Grigsby
, Rosemary J. Steinbach
, Alec J. Hirsch
, Rhonda P. MacAllister
, Heidi L. Pecoraro
, Lois M. Colgin
, Travis Hodge
, Daniel N. Streblow
, Suzette Tardif
, Jean L. Patterson
, Manasi Tamhankar
, Maxim Seferovic
, Kjersti M. Aagaard
, Claudia Sánchez San Martín

Charles Y. Chiu, Antonito T. Panganiban, Ronald S. Veazey, Xiaolei Wang, Nicholas J. Maness, Margaret H. Gilbert, Rudolf P. Bohm, Kristina M. Adams Waldorf, Michael Gale, Lakshmi Rajagopal, Charlotte E. Hotchkiss, Emma L. Mohr, Saverio V. Capuano, Heather A. Simmons, Andres Mejia, Thomas C. Friedrich, Thaddeus G. Golos, David H. O’Connor

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Original language	English (US)
Pages (from-to)	1104-1107
Number of pages	4
Journal	Nature Medicine
Volume	24
Issue number	8
DOIs	https://doi.org/10.1038/s41591-018-0088-5
State	Published - Aug 1 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018, The Author(s).

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41591-018-0088-5

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Dudley, D. M., Van Rompay, K. K., Coffey, L. L., Ardeshir, A., Keesler, R. I., Bliss-Moreau, E., Grigsby, P. L., Steinbach, R. J., Hirsch, A. J., MacAllister, R. P., Pecoraro, H. L., Colgin, L. M., Hodge, T., Streblow, D. N., Tardif, S., Patterson, J. L., Tamhankar, M., Seferovic, M., Aagaard, K. M., ... O’Connor, D. H. (2018). Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nature Medicine, 24(8), 1104-1107. https://doi.org/10.1038/s41591-018-0088-5

Dudley, DM, Van Rompay, KK, Coffey, LL, Ardeshir, A, Keesler, RI, Bliss-Moreau, E, Grigsby, PL, Steinbach, RJ, Hirsch, AJ, MacAllister, RP, Pecoraro, HL, Colgin, LM, Hodge, T, Streblow, DN, Tardif, S, Patterson, JL, Tamhankar, M, Seferovic, M, Aagaard, KM, Martín, CSS, Chiu, CY, Panganiban, AT, Veazey, RS, Wang, X, Maness, NJ, Gilbert, MH, Bohm, RP, Adams Waldorf, KM, Gale, M, Rajagopal, L, Hotchkiss, CE, Mohr, EL, Capuano, SV, Simmons, HA, Mejia, A, Friedrich, TC, Golos, TG & O’Connor, DH 2018, 'Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates', Nature Medicine, vol. 24, no. 8, pp. 1104-1107. https://doi.org/10.1038/s41591-018-0088-5

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title = "Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates",

abstract = "Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26\% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.",

author = "Dudley, \{Dawn M.\} and \{Van Rompay\}, \{Koen K.\} and Coffey, \{Lark L.\} and Amir Ardeshir and Keesler, \{Rebekah I.\} and Eliza Bliss-Moreau and Grigsby, \{Peta L.\} and Steinbach, \{Rosemary J.\} and Hirsch, \{Alec J.\} and MacAllister, \{Rhonda P.\} and Pecoraro, \{Heidi L.\} and Colgin, \{Lois M.\} and Travis Hodge and Streblow, \{Daniel N.\} and Suzette Tardif and Patterson, \{Jean L.\} and Manasi Tamhankar and Maxim Seferovic and Aagaard, \{Kjersti M.\} and Mart{\'i}n, \{Claudia S{\'a}nchez San\} and Chiu, \{Charles Y.\} and Panganiban, \{Antonito T.\} and Veazey, \{Ronald S.\} and Xiaolei Wang and Maness, \{Nicholas J.\} and Gilbert, \{Margaret H.\} and Bohm, \{Rudolf P.\} and \{Adams Waldorf\}, \{Kristina M.\} and Michael Gale and Lakshmi Rajagopal and Hotchkiss, \{Charlotte E.\} and Mohr, \{Emma L.\} and Capuano, \{Saverio V.\} and Simmons, \{Heather A.\} and Andres Mejia and Friedrich, \{Thomas C.\} and Golos, \{Thaddeus G.\} and O{\textquoteright}Connor, \{David H.\}",

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doi = "10.1038/s41591-018-0088-5",

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AU - Ardeshir, Amir

AU - Keesler, Rebekah I.

AU - Bliss-Moreau, Eliza

AU - Grigsby, Peta L.

AU - Steinbach, Rosemary J.

AU - Hirsch, Alec J.

AU - MacAllister, Rhonda P.

AU - Pecoraro, Heidi L.

AU - Colgin, Lois M.

AU - Hodge, Travis

AU - Streblow, Daniel N.

AU - Tardif, Suzette

AU - Patterson, Jean L.

AU - Tamhankar, Manasi

AU - Seferovic, Maxim

AU - Aagaard, Kjersti M.

AU - Martín, Claudia Sánchez San

AU - Chiu, Charles Y.

AU - Panganiban, Antonito T.

AU - Veazey, Ronald S.

AU - Wang, Xiaolei

AU - Maness, Nicholas J.

AU - Gilbert, Margaret H.

AU - Bohm, Rudolf P.

AU - Adams Waldorf, Kristina M.

AU - Gale, Michael

AU - Rajagopal, Lakshmi

AU - Hotchkiss, Charlotte E.

AU - Mohr, Emma L.

AU - Capuano, Saverio V.

AU - Simmons, Heather A.

AU - Mejia, Andres

AU - Friedrich, Thomas C.

AU - Golos, Thaddeus G.

AU - O’Connor, David H.

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JF - Nature Medicine

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Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Abstract

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