miRNA signature of schwannomas: Possible role(s) of "tumor: Suppressor" miRNAs in benign tumors

Erdogan Pekcan Erkan, Xandra O. Breakefield, Okay Saydam

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


miRNAs have been recently implicated as drivers in several carcinogenic processes, where they can act either as oncogenes or as tumor suppressors. Schwannomas arise from Schwann cells, the myelinating cells of the peripheral nervous system. These benign tumors typically result from loss of the neurofibromatosis type 2 (NF2) tumor suppressor gene. We have recently carried out high-throughput miRNA expression profiling of human vestibular schwannomas using an array representing 407 known miRNAs in order to explore the role of miRNAs in the tumorigenesis of schwannomas. We found that miR-7 functions as a "tumor suppressor" by targeting proteins in three major oncogenic pathways - EGFR, Pak1, and Ack1. Interestingly, in this study, we also observed that several previously described potential tumor suppressor miRNAs that are down-regulated in malignant tumors were up-regulated in schwannomas. Here we discuss the possibility that "tumor suppressor" miRNAs may play a role in the transition stage(s) of cancer from benign to malignant forms.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
Issue number3
StatePublished - 2011
Externally publishedYes

Bibliographical note

Copyright 2017 Elsevier B.V., All rights reserved.


  • Ack1
  • Benign tumors
  • Neurofibromatosis 2 (NF2)
  • Schwannomas
  • Tumor suppressor miRNAs
  • miR-7

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