MiRNA Regulation through ligand occupancy of a nuclear hormone receptor

Ann E. Rougvie

doi:10.1126/scisignal.284pe52

MiRNA Regulation through ligand occupancy of a nuclear hormone receptor

Ann E. Rougvie

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

MicroRNAs (miRNAs) posttranscriptionally regulate gene expression, but the factors that direct transcription of miRNAs are not well characterized. Activation versus repression of key developmental miRNAs in Caenorhabditis elegans is directly mediated by ligand occupancy of a nuclear hormone receptor that acts to couple nutrient availability to developmental programs.

Original language	English (US)
Pages (from-to)	pe52
Journal	Science signaling
Volume	2
Issue number	84
DOIs	https://doi.org/10.1126/scisignal.284pe52
State	Published - Aug 18 2009

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10.1126/scisignal.284pe52

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abstract = "MicroRNAs (miRNAs) posttranscriptionally regulate gene expression, but the factors that direct transcription of miRNAs are not well characterized. Activation versus repression of key developmental miRNAs in Caenorhabditis elegans is directly mediated by ligand occupancy of a nuclear hormone receptor that acts to couple nutrient availability to developmental programs.",

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MiRNA Regulation through ligand occupancy of a nuclear hormone receptor

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