miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma

Paige E. Bennett, Lynne Bemis, David A. Norris, Yiqun G. Shellman

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Melanoma is a very aggressive skin cancer with increasing incidence worldwide. MicroRNAs are small, noncoding RNAs that regulate gene expression of targeted gene(s). The hallmark of cancer model outlined by Hanahan and Weinberg offers a meaningful framework to consider the roles of microRNAs in melanoma development and progression. In this systematic review of the literature, we associate what is known about deregulation of microRNAs and their targeted genes in melanoma development with the hallmarks and characteristics of cancer. The diagnostic and therapeutic potential of microRNAs for future melanoma management will also be discussed.

Original languageEnglish (US)
Pages (from-to)1049-1059
Number of pages11
JournalPhysiological genomics
Volume45
Issue number22
DOIs
StatePublished - Nov 15 2013

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Keywords

  • BRAF
  • MITF
  • miR-137
  • miR-18b
  • miR-214

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