Minimal clinically important worsening on the progressive supranuclear Palsy Rating Scale

Sarah Hewer, Sue Varley, Adam L. Boxer, Eldho Paul, David R. Williams, Jean Phllippe Azulay, Reiner Benecke, Bradley F. Boeve, Yvette M. Bordelon, Adam L. Boxer, Bruce Miller, David J. Burn, Dennis Chan, Jean Christophe Corvol, Philippe Couratier, Praveen Dayalu, Rachelle Doody, Erika Driver-Dunkley, Joseph Ferrara, Lawrence I. GolbeNeill R. Graff-Radford, David Grimes, Murray Grossman, Steven Gunzler, Argyle Elizabeth Hillis, Günter Höglinger, Lawrence Honig, Anthony Lang, Andrew Lees, Irene Litvan, Stuart H. Isaacson, Joseph Jankovic, Mandar S. Jog, Daniel I. Kaufer, Rajeev Kumar, Anne Louise Lafontaine, Julie Leegwater-Kim, Stephanie Lessig, Mark F. Lew, Axel Lipp, Iryna Lobach, Stefan P. Lorenzl, Albert Ludolph, Connie Marras, Scott McGinnis, Brit Mollenhauer, Rajesh Pahwa, Michel Panisset, Heinz Reichmann, David Williams, on behalf of the AL-108-231 Investigators

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Despite the widespread use of the Progressive Supranuclear Palsy Rating Scale (PSPRS), it is not known what change in this scale is meaningful for patients. Methods: We analyzed data from a large clinical trial in PSP-Richardson's syndrome (AL-108-231) to calculate minimal clinically important worsening. This was defined as the difference in mean change of PSPRS in subjects rated “a little worse” and those rated “unchanged” on the Clinicians' Global Impression of Change Scale. A multivariate analysis using logistic regression assessed the relationship between clinical worsening, PSPRS, depression, and activities of daily living. Results: The minimal clinically important worsening on the PSPRS was 5.7 points, corresponding to the mean decline over 6 months in the trial. Changes in activities of daily living and PSPRS were significantly associated with clinical worsening. Conclusions: Clinically meaningful change is measurable on the PSPRS over 6 months.

Original languageEnglish (US)
Pages (from-to)1574-1577
Number of pages4
JournalMovement Disorders
Issue number10
StatePublished - Oct 1 2016

Bibliographical note

Publisher Copyright:
© 2016 2016 International Parkinson and Movement Disorder Society


  • minimal clinically important change (MCIC)
  • progressive supranuclear palsy (PSP)
  • progressive supranuclear palsy rating scale (PSPRS)


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