Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration

Jingwei Xie; Sunil Kumar Boda; Hongjun Wang; Dong Wang; Richard A. Reinhardt

Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration

Jingwei Xie, Sunil Kumar Boda, Hongjun Wang, Dong Wang, Richard A. Reinhardt

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Statement of Purpose: The issue of bone loss in the oral cavity continues to be a perennial problem, especially in the older populations. With the high incidence of dental implants/ fixtures for missing teeth, the success of the surgical procedures in restorative dentistry is dictated by the quality and quantity of the supporting alveolar bone. In order to address the problem of alveolar bone loss and defects due to tumor, periodontitis or even post-extraction remodeling, the present study is the first report on the application of mineralized nanofiber fragments coupled with calcium binding osteoinductive BMP-2 peptides as synthetic graft material for oral bone regeneration. The ease of fabrication and application of cryocut mineralized nanofiber fragments as maxillofacial bone defect fillers present a promising alternative to the current dental bone graft formulations. Furthermore, the nanofiber segments may be utilized for other biomedical applications including soft tissue engineering and wound healing.

Original language	English (US)
Title of host publication	Society for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publication	The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Publisher	Society for Biomaterials
Pages	485
Number of pages	1
ISBN (Electronic)	9781510883901
State	Published - 2019
Event	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: Apr 3 2019 → Apr 6 2019

Publication series

Name	Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume	40
ISSN (Print)	1526-7547

Conference

Conference	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/Territory	United States
City	Seattle
Period	4/3/19 → 4/6/19

Bibliographical note

Publisher Copyright:
© 2019 Omnipress - All rights reserved.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

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Xie, J., Boda, S. K., Wang, H., Wang, D., & Reinhardt, R. A. (2019). Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (pp. 485). (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration. / Xie, Jingwei; Boda, Sunil Kumar; Wang, Hongjun et al.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. p. 485 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Xie, J, Boda, SK, Wang, H, Wang, D & Reinhardt, RA 2019, Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, pp. 485, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Xie J, Boda SK, Wang H, Wang D, Reinhardt RA. Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. p. 485. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

Xie, Jingwei ; Boda, Sunil Kumar ; Wang, Hongjun et al. / Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. pp. 485 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

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abstract = "Statement of Purpose: The issue of bone loss in the oral cavity continues to be a perennial problem, especially in the older populations. With the high incidence of dental implants/ fixtures for missing teeth, the success of the surgical procedures in restorative dentistry is dictated by the quality and quantity of the supporting alveolar bone. In order to address the problem of alveolar bone loss and defects due to tumor, periodontitis or even post-extraction remodeling, the present study is the first report on the application of mineralized nanofiber fragments coupled with calcium binding osteoinductive BMP-2 peptides as synthetic graft material for oral bone regeneration. The ease of fabrication and application of cryocut mineralized nanofiber fragments as maxillofacial bone defect fillers present a promising alternative to the current dental bone graft formulations. Furthermore, the nanofiber segments may be utilized for other biomedical applications including soft tissue engineering and wound healing.",

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Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration

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