Mineral coatings for temporally controlled delivery of multiple proteins

Jae Sung Lee; Darilis Suarez-Gonzalez; William L. Murphy

doi:10.1002/adma.201100060

Mineral coatings for temporally controlled delivery of multiple proteins

Jae Sung Lee
, Darilis Suarez-Gonzalez
, William L. Murphy

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Mineral coatings are presented as a temporally controllable protein release system on a common orthopedic device material, β-tricalcium phosphate (β-TCP). Proteins are bound to coatings via electrostatic interactions and release of one or more proteins is temporally controlled in a predictable manner by modulating the physicochemical properties of mineral coatings, including morphology and dissolution rate.

Original language	English (US)
Pages (from-to)	4279-4284
Number of pages	6
Journal	Advanced Materials
Volume	23
Issue number	37
DOIs	https://doi.org/10.1002/adma.201100060
State	Published - Oct 4 2011
Externally published	Yes

Keywords

biomimetics
drug delivery
functional coatings
medical applications
tissue engineering

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10.1002/adma.201100060

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title = "Mineral coatings for temporally controlled delivery of multiple proteins",

abstract = "Mineral coatings are presented as a temporally controllable protein release system on a common orthopedic device material, β-tricalcium phosphate (β-TCP). Proteins are bound to coatings via electrostatic interactions and release of one or more proteins is temporally controlled in a predictable manner by modulating the physicochemical properties of mineral coatings, including morphology and dissolution rate.",

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author = "Lee, \{Jae Sung\} and Darilis Suarez-Gonzalez and Murphy, \{William L.\}",

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doi = "10.1002/adma.201100060",

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AU - Suarez-Gonzalez, Darilis

AU - Murphy, William L.

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Y1 - 2011/10/4

N2 - Mineral coatings are presented as a temporally controllable protein release system on a common orthopedic device material, β-tricalcium phosphate (β-TCP). Proteins are bound to coatings via electrostatic interactions and release of one or more proteins is temporally controlled in a predictable manner by modulating the physicochemical properties of mineral coatings, including morphology and dissolution rate.

AB - Mineral coatings are presented as a temporally controllable protein release system on a common orthopedic device material, β-tricalcium phosphate (β-TCP). Proteins are bound to coatings via electrostatic interactions and release of one or more proteins is temporally controlled in a predictable manner by modulating the physicochemical properties of mineral coatings, including morphology and dissolution rate.

KW - biomimetics

KW - drug delivery

KW - functional coatings

KW - medical applications

KW - tissue engineering

UR - https://www.scopus.com/pages/publications/80054690025

UR - https://www.scopus.com/pages/publications/80054690025#tab=citedBy

U2 - 10.1002/adma.201100060

DO - 10.1002/adma.201100060

M3 - Article

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AN - SCOPUS:80054690025

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VL - 23

SP - 4279

EP - 4284

JO - Advanced Materials

JF - Advanced Materials

IS - 37

ER -

Mineral coatings for temporally controlled delivery of multiple proteins

Abstract

Keywords

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