Mild to moderate hyperhomocysteinaemia in cardiovascular disease

An S. De Vriese, Johan H. De Sutter, Marc De Buyzere, Daniel Duprez

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Elevated serum levels of homocysteine, a sulphur-containing amino acid, are increasingly recognized as an independent risk factor for atherosclerotic and thrombotic vascular disease. Presence of a thermolabile variant of methylenetetrahydrofolatereductase and an inadequate folate status are the most common causes of hyperhomocysteinaemia. Homocysteine damages the vessel wall mainly through generation of oxygen radicals and creates a prothrombotic environment. In the majority of cases, normalization of homocysteine levels can be achieved with administration of vitamins of the B-group. The effect of this treatment on cardiovascular outcome, however, remains undefined.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalActa cardiologica
Issue number6
StatePublished - Dec 1 1998


  • Atherosclerosis
  • Homocysteine
  • Risk factor
  • Screening
  • Thrombosis
  • Treatment


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